| Customization: | Available |
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| CAS No.: | 1801959-12-5 |
| Formula: | Chons |
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| Purity | 99%+ | Private customization | 2mg 5mg 10mg 15mg 20mg 30me etc. | |
| Cleanliness | Sterile | Transportation time | 7-15days | |
| Actual peptide content | Exceed the standard | Disguise | Can provide | |
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PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin which binds to TREK-1. TREK-1 is found in regions of the brain controlling mood, memory, and learning. PE-22-28 is being researched for applications including antidepressant activity, learning, stroke recovery and neurodegeneative diseases such as Alzheimer's.
PE-22-28 is a synthetic derivative of the naturally occurring peptide spadin. Spadin is asecreted peptide derived from sortilin. lt is an antagonist of the TREK-1 (TWIK-relatedpotassium channel) receptor, a two-pore potassium channel identified as a potentialtarget in the treatment of depression and as a possible neurogenic regulator. Earlystudies in mice have shown that a deletion of the TREK-1 receptor makes them resistantto depression. Similarly, treatment with sortilin leads to resistance to depression booststhe growth of both neurons and the synaptic interconnections between neurons[1].
Interestingly, shortened analogs of spadin actually show better TREK-1 inhibition thanspadin itself. PE-22-28 is the representative peptide for this group of synthetic spadinanalogs.PE-22-28 has been shown to be more stable and have improved antidepressantactivity and neurogenic properties over the naturally occurring spadin.
Peptides are composed of amino acids linked together by Peptides. The smallest Peptides can consist of three amino acids, such as thyrotropin-releasing hormone (TRH). Most Peptides can be made up of dozens or even hundreds of amino acids. The primary secretion organs for Peptides are the hypothalamus and the pituitary gland; however, Peptides have also been found in other organs, such as the gastrointestinal tract, brain tissue, lungs, and heart. Peptides are a type of endogenous substance that consists of protein chains containing polypeptide compounds. Examples of Peptides include thyrotropin-releasing hormone, Peptides and its analogs, Peptides and its analogs, adrenocorticotropic hormone, gonadotropins, Peptides and its analogs, Peptides-like Peptides, calcitonin, and parathyroid hormone.
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3:Anti-Aging Effects: They are frequently used in the field of cosmetics.
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